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Larry Snyder
Email: larry at eye-hand.wustl.edu
larry.cv
Education
Princeton University |
A.B. English |
1982 |
University of Rochester |
M.D. Medicine |
1992 |
University of Rochester |
Ph.D. Physiology |
1992 |
Thesis: The effect of vergence angle and axis of head rotation
on the vestibulo-ocular reflex (VOR) and on the discharge of cerebellar
flocculus Purkinje cells in macaque monkey.
Advisor: W. Michael King
Employment
1992-1994
Post-doctoral Fellow, Massachusetts Institute of
Technology
Principal investigator: Richard Andersen
1994-1995
Senior Research Associate, California Institute
of Technology
Principal investigator: Richard Andersen
1996-2004
Assistant Professor of Neurobiology, Washington University
2004-2010
Associate Professor of Neurobiology, Washington University
2010-
Professor of Neurobiology, Washington University
2012-
Co-Director of the Graduate Program in Neuroscience, Washington University
Fellowships and Awards
Medical Scientist Training Program |
1982-1992 |
ARVO Travel Fellowship |
1990 |
Bartlett Prize |
1990 |
Robert Cates Award for Excellence in Science and Medicine |
1992 |
McDonnell-Pew Postdoctoral Fellowship |
1992-1994 |
Della Martin Foundation Postdoctoral Fellowship |
1994-1995 |
Sloan Fellowship |
1998-1999 |
National Eye Institute Investigator |
2000-2004 |
Klingenstein Fellowship |
1998-2001 |
EJLB Foundation Scholar Fellow |
2002-2004 |
Family
Married to Tara Nealey, Biotech Patent Attorney
Children: Cassandra (Washington University Class of 2014) and
Braham (Washington University Class of 2016)
Laboratory
Our laboratory studies how locations in space are represented in the cerebral
cortex, and how those representations are used to guide eye
and arm movements. More generally, how is
sensory spatial information transformed into commands
for movement? And, given a system in which this occurs,
how can we analyze that transformation?
Parietal cortex has long been implicated in the transformation of
visual sensory information
into motor commands. A patient with unilateral parietal
damage may ignore objects in one half of the world, clothe only half of their
body or eat from only half of their plate. Spatial memory is
affected, and there are often motor deficits as well.
In order to understand the role of the parietal cortex in representing space
and subserving movement, we record from individual neurons in
macaque monkeys while they perform complex visuo-motor tasks. The animals are
trained to look at and reach for colored spots of light -
a monkey video game. We ask how the locations of these spots are represented
by neural activity in the brain. What frame of reference is
used? Is there a single, generic representation or multiple special purpose
representations? How is spatial information from other sensory
systems combined with visually-derived information? How does the nature of the
task, and what the animal intends to do, affect parietal
processing? Is parietal cortex specifically involved in the learning of new
sensory-motor mappings, or in coordinating eye and hand
movement?
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