Effect of Reversible Inactivation of Macaque Lateral Intraparietal Area on Saccades and Search
Yuqing Liu &
Lawrence H. Snyder
Washington University
School of Medicine
St. Louis, MO
Area LIP, in the posterior parietal cortex, is involved in
the sensorimotor transformation for eye movements. LIP has been hypothesized to either play a specific role in
specifying targets for possible eye movements, or as playing a more general
role in registering salient spatial locations. An oculomotor role was supported by the study of Li &
Andersen (1999), who found that reversible inactivation of LIP with muscimol
led to delayed reaction times for visually- and memory-guided saccades. A non-specific role was supported by
studies of Wardak and colleagues (2002, 2004), who found normal saccadic
reaction times to single targets, but prolonged search times. We repeated these experiments,
coinjecting manganese with muscimol so that injection sites could be directly
visualized using anatomical magnetic resonance imaging. Data from one animal
show deficits in both memory-guided saccade reaction times and in search times,
and no effects in memory-guided reach reaction time. We are currently testing the hypothesis that injection sites
underlying saccadic and search effects may be dissociable.
Gordon Research Conference 2007
Bates College in Lewiston, ME